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Total 1353 results found since Jan 2013.

Molecules, Vol. 24, Pages 1182: A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity
This study aims to bring together information on the phenolic compounds present in the bark of woody vascular plants by discussing extraction methods, the chemical composition of the extracts and potential biological effects. The literature data used in this paper were collected via PubMed (2004–2019). Search terms were: bark, rhytidome, woody vascular plant, polyphenols, phenolic compounds, biologic activity, antioxidant, immunostimulatory, antimutagenic, antibacterial, anti-inflammatory, and antitumoral. This paper intends to highlight the fact that the polyphenolic extracts obtained from the bark of woody vascular pla...
Source: Molecules - March 25, 2019 Category: Chemistry Authors: Corneliu Tanase Sanda Co șarcă Daniela-Lucia Muntean Tags: Review Source Type: research

Molecules, Vol. 23, Pages 2106: Mechanisms of Protein Search for Targets on DNA: Theoretical Insights
eisky Protein-DNA interactions are critical for the successful functioning of all natural systems. The key role in these interactions is played by processes of protein search for specific sites on DNA. Although it has been studied for many years, only recently microscopic aspects of these processes became more clear. In this work, we present a review on current theoretical understanding of the molecular mechanisms of the protein target search. A comprehensive discrete-state stochastic method to explain the dynamics of the protein search phenomena is introduced and explained. Our theoretical approach utilizes a first-pa...
Source: Molecules - August 22, 2018 Category: Chemistry Authors: Alexey A. Shvets Maria P. Kochugaeva Anatoly B. Kolomeisky Tags: Review Source Type: research

Molecules, Vol. 26, Pages 1523: Arterial Blood Pressure Variability and Other Vascular Factors Contribution to the Cognitive Decline in Parkinson ’s Disease
Molecules, Vol. 26, Pages 1523: Arterial Blood Pressure Variability and Other Vascular Factors Contribution to the Cognitive Decline in Parkinson’s Disease Molecules doi: 10.3390/molecules26061523 Authors: Anna Pierzchlińska Magdalena Kwaśniak-Butowska Jarosław Sławek Marek Droździk Monika Białecka Dementia is one of the most disabling non-motor symptoms in Parkinson’s disease (PD). Unlike in Alzheimer’s disease, the vascular pathology in PD is less documented. Due to the uncertain role of commonly investigated metabolic or vascular factors, e.g., hypertension or diabetes, other factors correspo...
Source: Molecules - March 10, 2021 Category: Chemistry Authors: Anna Pierzchli ńska Magdalena Kwa śniak-Butowska Jaros ław Sławek Marek Dro ździk Monika Bia łecka Tags: Review Source Type: research

Molecules, Vol. 26, Pages 7111: Advances in Radiopharmaceutical Sciences for Vascular Inflammation Imaging: Focus on Clinical Applications
gne Biomedical imaging technologies offer identification of several anatomic and molecular features of disease pathogenesis. Molecular imaging techniques to assess cellular processes in vivo have been useful in advancing our understanding of several vascular inflammatory diseases. For the non-invasive molecular imaging of vascular inflammation, nuclear medicine constitutes one of the best imaging modalities, thanks to its high sensitivity for the detection of probes in tissues. 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) is currently the most widely used radiopharmaceutical for molecular imaging of vascular inflammatory...
Source: Molecules - November 24, 2021 Category: Chemistry Authors: Kevin Prigent Jonathan Vigne Tags: Review Source Type: research

Molecules, Vol. 27, Pages 5628: Effects of Lycium barbarum L. Polysaccharides on Vascular Retinopathy: An Insight Review
Xianrong Lai Vascular retinopathy is a pathological change in the retina caused by ocular or systemic vascular diseases that can lead to blurred vision and the risk of blindness. Lycium barbarum polysaccharides (LBPs) are extracted from the fruit of traditional Chinese medicine, L. barbarum. They have strong biological activities, including immune regulation, antioxidation, and neuroprotection, and have been shown to improve vision in numerous studies. At present, there is no systematic literature review of LBPs on vascular retinal prevention and treatment. We review the structural characterization and extraction meth...
Source: Molecules - August 31, 2022 Category: Chemistry Authors: Chunhong Yang Qi Zhao Shiling Li Lili Pu Liqiong Yu Yaqin Liu Xianrong Lai Tags: Review Source Type: research

Molecules, Vol. 25, Pages 187: Quercetin Exerts Age-Dependent Beneficial Effects on Blood Pressure and Vascular Function, But Is Inefficient in Preventing Myocardial Ischemia-Reperfusion Injury in Zucker Diabetic Fatty Rats
Conclusions: QCT might be beneficial for vascular function in diabetes type 2; however, increasing age and/or progression of diabetes may confound its vasculoprotective effects. QCT seems to be inefficient in preventing myocardial I/R injury in type 2 diabetes and/or higher age. Impaired activation of PI3K/Akt kinase pathway might be, at least in part, responsible for failing cardioprotection in these subjects.
Source: Molecules - January 1, 2020 Category: Chemistry Authors: Kristina Ferenczyova Barbora Kalocayova Lucia Kindernay Marek Jelemensky Peter Balis Andrea Berenyiova Anna Zemancikova Veronika Farkasova Matus Sykora Lubomira Tothova Tomas Jasenovec Jana Radosinska Jozef Torok Sona Cacanyiova Miroslav Barancik Monika B Tags: Article Source Type: research

Molecules, Vol. 25, Pages 3105: Chemical Fingerprinting, Isolation and Characterization of Polyphenol Compounds from Heliotropium taltalense (Phil.) I.M. Johnst and Its Endothelium-Dependent Vascular Relaxation Effect in Rat Aorta
i Cifuentes Heliotropium taltalense is an endemic species of the northern coast of Chile and is used as folk medicine. The polyphenolic composition of the methanolic and aqueous extract of the endemic Chilean species was investigated using Ultrahigh-Performance Liquid Chromatography, Heated Electrospray Ionization and Mass Spectrometry (UHPLC-Orbitrap-HESI-MS). Fifty-three compounds were detected, mainly derivatives of benzoic acid, flavonoids, and some phenolic acids. Furthermore, five major compounds were isolated by column chromatography from the extract, including four flavonoids and one geranyl benzoic acid deriva...
Source: Molecules - July 7, 2020 Category: Chemistry Authors: Ruth E. Barrientos Mario J. Simirgiotis Javier Palacios Adri án Paredes Jorge B órquez Alejandra Bravo Fredi Cifuentes Tags: Article Source Type: research

Molecules, Vol. 26, Pages 667: Unraveling the Roles of Vascular Proteins Using Proteomics
iqiang Lv Vascular bundles play important roles in transporting nutrients, growth signals, amino acids, and proteins between aerial and underground tissues. In order to understand these sophisticated processes, a comprehensive analysis of the roles of the components located in the vascular tissues is required. A great deal of data has been obtained from proteomic analyses of vascular tissues in plants, which mainly aim to identify the proteins moving through the vascular tissues. Here, different aspects of the phloem and xylem proteins are reviewed, including their collection methods, and their main biological roles in...
Source: Molecules - January 27, 2021 Category: Chemistry Authors: Yan Liu Tianbao Lin Maria Valderrama Valencia Cankui Zhang Zhiqiang Lv Tags: Review Source Type: research

Molecules, Vol. 26, Pages 2551: Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors
Ralph P. Mason Tumor vasculature proliferates rapidly, generally lacks pericyte coverage, and is uniquely fragile making it an attractive therapeutic target. A subset of small-molecule tubulin binding agents cause disaggregation of the endothelial cytoskeleton leading to enhanced vascular permeability generating increased interstitial pressure. The resulting vascular collapse and ischemia cause downstream hypoxia, ultimately leading to cell death and necrosis. Thus, local damage generates massive amplification and tumor destruction. The tumor vasculature is readily accessed and potentially a common target irrespective ...
Source: Molecules - April 27, 2021 Category: Chemistry Authors: Li Liu Devin O ’Kelly Regan Schuetze Graham Carlson Heling Zhou Mary Lynn Trawick Kevin G. Pinney Ralph P. Mason Tags: Review Source Type: research

Molecules, Vol. 26, Pages 4649: Characterization of a Water-Dispersed Biodegradable Polyurethane-Silk Composite Sponge Using 13C Solid-State Nuclear Magnetic Resonance as Coating Material for Silk Vascular Grafts with Small Diameters
In this study, we developed a softer SF graft by coating water-dispersed biodegradable polyurethane (PU) based on polycaprolactone and an SF composite sponge on the knitted SF vascular graft. Three kinds of 13C solid-state nuclear magnetic resonance (NMR), namely carbon-13 (13C) cross-polarization/magic angle spinning (MAS), 13C dipolar decoupled MAS, and 13C refocused insensitive nuclei enhanced by polarization transfer (r-INEPT) NMR, were used to characterize the PU-SF coating sponge. Especially the 13C r-INEPT NMR spectrum of water-dispersed biodegradable PU showed that both main components of the non-crystalline domain...
Source: Molecules - July 31, 2021 Category: Chemistry Authors: Takashi Tanaka Yusuke Ibe Takaki Jono Ryo Tanaka Akira Naito Tetsuo Asakura Tags: Article Source Type: research

Molecules, Vol. 26, Pages 7149: SugarDrawer: A Web-Based Database Search Tool with Editing Glycan Structures
Yamada In life science fields, database integration is progressing and contributing to collaboration between different research fields, including the glycosciences. The integration of glycan databases has greatly progressed collaboration worldwide with the development of the international glycan structure repository, GlyTouCan. This trend has increased the need for a tool by which researchers in various fields can easily search glycan structures from integrated databases. We have developed a web-based glycan structure search tool, SugarDrawer, which supports the depiction of glycans including ambiguity, such as glyca...
Source: Molecules - November 25, 2021 Category: Chemistry Authors: Tsuchiya Matsubara Aoki-Kinoshita Yamada Tags: Technical Note Source Type: research

Molecules, Vol. 27, Pages 5100: Tetrahydrocurcumin-Related Vascular Protection: An Overview of the Findings from Animal Disease Models
nov Feng Wang Tetrahydrocurcumin (THC), one of the major metabolites of CUR, possesses several CUR-like pharmacological effects; however, its mechanisms of action are largely unknown. This manuscript aims to summarize the literature on the preventive role of THC on vascular dysfunction and the development of hypertension by exploring the effects of THC on hemodynamic status, aortic elasticity, and oxidative stress in vasculature in different animal models. We review the protective effects of THC against hypertension induced by heavy metals (cadmium and iron), as well as its impact on arterial stiffness and vascular r...
Source: Molecules - August 10, 2022 Category: Chemistry Authors: Li Zhang Changhu Li Sicheng Wang Dimiter Avtanski Nikola Hadzi-Petrushev Vadim Mitrokhin Mitko Mladenov Feng Wang Tags: Review Source Type: research

Molecules, Vol. 27, Pages 7025: Tripeptide Leu-Ser-Trp Regulates the Vascular Endothelial Cells Phenotype Switching by Mediating the Vascular Smooth Muscle Cells-Derived Small Extracellular Vesicles Packaging of miR-145
ouming Zhao Tripeptide LSW, initially identified as a potent ACE inhibitory peptide from soybean protein, was recently reported to exert a protective effect against angiotensin II-induced endothelial dysfunction via extracellular vesicles (EVs). However, the molecular mechanisms, especially in lipid accumulation-induced atherosclerosis, still remain unclear. The study aimed to investigate whether the protective effects of LSW against endothelial dysfunction on vascular endothelial cells (VECs) was via vascular smooth muscle cells (VSMCs)-derived miRNA-145 packaged in EVs. The miRNA-145 was concentrated in EVs from LSW-...
Source: Molecules - October 18, 2022 Category: Chemistry Authors: Tianyuan Song Minzhi Zhou Wen Li Lin Zheng Jianping Wu Mouming Zhao Tags: Article Source Type: research

Molecules, Vol. 27, Pages 7524: Progress in the Preclinical and Clinical Study of Resveratrol for Vascular Metabolic Disease
en Zilun Li Vascular metabolic dysfunction presents in various diseases, such as atherosclerosis, hypertension, and diabetes mellitus. Due to the high prevalence of these diseases, it is important to explore treatment strategies to protect vascular function. Resveratrol (RSV), a natural polyphenolic phytochemical, is regarded as an agent to regulate metabolic pathways. Many studies have proven that RSV has beneficial effects on improving metabolism in endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), which provide new directions to treat vascular metabolic diseases. Herein, we overviewed that RSV coul...
Source: Molecules - November 3, 2022 Category: Chemistry Authors: Dongxiao Fan Chenshu Liu Zhongyu Zhang Kan Huang Tengyao Wang Sifan Chen Zilun Li Tags: Review Source Type: research

Molecules, Vol. 28, Pages 1693: A Low Concentration of Citreoviridin Prevents Both Intracellular Calcium Deposition in Vascular Smooth Muscle Cell and Osteoclast Activation In Vitro
ng Lee Soyeon Lim Vascular calcification (VC) and osteoporosis are age-related diseases and significant risk factors for the mortality of elderly. VC and osteoporosis may share common risk factors such as renin-angiotensin system (RAS)-related hypertension. In fact, inhibitors of RAS pathway, such as angiotensin type 1 receptor blockers (ARBs), improved both vascular calcification and hip fracture in elderly. However, a sex-dependent discrepancy in the responsiveness to ARB treatment in hip fracture was observed, possibly due to the estrogen deficiency in older women, suggesting that blocking the angiotensin signalin...
Source: Molecules - February 10, 2023 Category: Chemistry Authors: Seongtae Jeong Bok-Sim Lee Seung Eun Jung Yoojin Yoon Byeong-Wook Song Il-Kwon Kim Jung-Won Choi Sang Woo Kim Seahyoung Lee Soyeon Lim Tags: Article Source Type: research